临床与病理杂志
J Clin Pathol Res 2020, 40(1) 136收稿日期(Date of reception)：2019–05–05
通信作者(Corresponding author)：杨海玉，Email:
olive
基金项目(Foundation item)：国家自然科学基金(81760038)；江西省卫生厅科技计划(20161014)。This work was supported by the National Natural Science Fund Project (81760038) and Jiangxi Province Health Department Science and Technology Plan Project (20161014), China.活性氧(reactive oxygen species ，ROS)是生物
国际贸易学硕士
有氧代谢过程产生的化学活性分子，包括氧离
子、过氧化物和含氧自由基等。在病理条件下，
ROS 的产生和清除之间失去平衡，过高浓度的ROSsolemnly
可通过破坏核酸、蛋白质及脂质而产生细胞毒性，细胞内抗氧化酶对ROS 诱导的损伤具有保护作用。过氧化物酶(peroxiredoxin ，Prdx)是近年来发现的一组抗氧化酶蛋白家族，在哺乳类动物中通常包括6个亚型(Prdx1~6)，其主要功能是清除细胞内过氧化物。由于Prdx 的高丰度和强活性，人体细doi: 10.3978/j.i
combssn.2095-6959.2020.01.023View this articl e at: dx.doi/10.3978/j.issn.2095-6959.2020.01.023
过氧化物酶与急性髓系白血病的研究进展
koti
杨海玉
(江西省人民医院临床医学研究所，南昌 330006)
belton
gre机经[摘 要] 过氧化物酶(peroxiredoxin ，Prdx)是近年来发现的一组抗氧化酶蛋白家族，可通过调控细胞内活性
氧(reactive oxygen ，ROS)水平及相关细胞信号转导通路，进而干扰白血病细胞的增殖、凋亡和分
化。目前研究发现Prdx 的多个亚型与急性髓系白血病发生相关，其功能也不尽相同。未来研究需广州西点培训学校
要进一步阐明Prdx 不同亚型在白血病发生中的具体作用机制及其临床意义，从而为白血病治疗提
供新的靶点。
[关键词] 过氧化物酶；急性髓系白血病；抗氧化酶；氧化应激
Rearch progress of peroxiredoxin and acute
myeloid leukemia
YANG Haiyu
(Institute of Clinical Medical Science, Jiangxi Province People’s Hospital, Nanchang 330006, China)
Abstract Peroxiredoxin (Prdx) was a protein family of antioxidant enzymes discovered in recent year. Prdx would interfere
with the proliferation, apoptosis and differentiation of leukemia cells through regulating the level of reactive
oxygen species (ROS) in cells and related signaling pathways. At prent studies find that some subtypes of Prdx
ica
are associated with acute myeloid leukemia and their functions were also different in the mechanism. Future
rearches need to be further clarified the specific mechanism of different Prdx subtypes in the pathogenesis of
leukemia and their clinical significance, which may provide new targets for leukemia treatment.
简单意大利语学习Keywords peroxiredoxin; acute myeloid leukemia; antioxida; oxidative stress
