北京英语翻译中文摘要复发难治性AML的治疗善复发难治性白血病患者的长期预后。
关键词复发难治白血病地西他滨中剂量阿糖胞苷高三尖杉酯碱
第二部分强化预处理方案（IBU方案）行自体干细胞移植治疗
急性髓系白血病的疗效
目的探讨大剂量去甲氧柔红霉素(IDA)联合白消安(BU)组成的强化预处理方案（IBU方案）在未找到相合供者的急性髓系白血病(AML)临床预后不良组行自体造血干细胞移植（AHSCT）的疗效及安全性。
方法整理分析我科2011年4月～2014年3月未能找到合适供者的临床预后不良组AML患者10例应用该预处理方案进行AHSCT的资料，观察移植后造血重建时间、移植相关并发症和随访情况。
美国国会大厦暴力事件结果10例患者均顺利获得造血重建。随访时间至2015年3月，9例患者存活，中位随访时间为20个月（10～38月），80%患者存活，其中有70%持续CR中。3例复发，分别于移植后3个月、5个月、6个月复发，2例目前仍在治疗中，1例复发后并发脑出血死亡，累计总复发率约30%。
结论IBU作为预处理方案的AHSCT在临床预后不良组急性髓系白血病中有较好的疗效，不良反应可控，与传统的BuCy预处理方案相比有更好的无病生存率和较低的移植后复发率，可作为未找到合适供者而需要进行造血干细胞移植的预后不良组AML患者的另外一种替代选择。
关键词急性白血病预后不良大剂量去甲氧柔红霉素白消安自体干细胞移植
作者：程英英dear是什么意思中文
指导教师：曹祥山
复发难治性AML的治疗英文摘要
女生的英语名字The therapy of refractory and relapd AML
Abstract
Part One The rapeutic effects of demethylation combined Intermediate-do cytarabine regimen in the treatment of refractory and
relapd acute myeloid leukemia
Objective To obrve the therapeuticefects of demethylation combined intermediate-do cytarabine regimen in the treatment of refractory and relapd acute myeloid leukemia and explore the new solutions of tho patients in the clinical treatment.
Methods 12 patients who were diagnod as refractory and relapd acute myeloid leukemia were lected from Jan.2014 to Oct. 2014, on the basis of agreement of patients and their family members and refer to relevant references, we designed the chemotherapy regimens of DAC+FLAG + HHT and evaluated the curative effect and curity of the treatment.
Results (1).The adver reaction of chemotherapy was bone marrow suppression and condary infection. 12 patients had occurred four degree of hematologic adver reactions.10 patients with varying degrees of fever, including 6 cas were three to four infections. Pathogen detection discovers 1 ca of stenotrophomonas maltophilia. Bacterium found in 2 cas of oral fungus. It clears lung infection in 5 cas, urinary tract infection in 2 cas and skin soft tissue infection in 1 ca by imaging examination. The cond gastrointestinal adver reactions occurred in 3, three times in 1 ca. All of the patients appeared different degree of skin mucous membrane petechiae, there was no three to four degree of bleeding or liver or kidney impairment etc. No phenomenon of death becau of infection or bleeding.
(2) Review of the bone marrow aspiration after peripheral blood image restoration, 10 patients received complete remission (CR), 2 patients were non-remission (NR).The effective rate was 83.3%.Flow cytometry detect the minimal residual dia of leukemia of 10 patients in CR, All of th
em were below the detection limit.
(3)Follow-up the 10 patients of CR, 2 patients in complete remission (CR) move on hematopoietic stem cell, including 1 ca of allogeneic hematopoietic stem celltencent是什么意思
英文摘要复发难治性AML的治疗transplantation, sustained remission 3 months before. And another ca had haploid transplantation, which hematopoietic function had been reconstructed.6 cas go on regular chemotherapy after CR, and the partial matches have been found in the Chine marrow donor program (CDMP), subquent to stem cell transplantation.2 patients lost to follow-up becau of economic reasons to give up treatment. For 2 patients of NR, there was one ca died of intracranial hemorrhage in the process of chemotherapy, another ca of primary resistance induced persist for many times, which was in palliative care still.
Conclusions Demethylate combined chemotherapy regimens is a well-effective and relatively safe treatment regimen for patients with refractory or relapd acute leukemia bad on our small samples of data, it may be improve the long-term outcome of tho patients by increasing sample of study.
Key words Refractory and relapd acute leukemia; Decitabine: Intermediate-do cytarabine; Hom
理念是什么意思
在线学习德语oharringtomine
Part Two Curative effect of strengthening preconditioning regimen (IBU) for autologous hematopoietic stem cell transplantation in the treatment of
acute myeloid leukemia
Objective Exploring the curative effect and curity of preconditioning regimen which is high dos idarubicin combine busulphan (IBU) for autologous stem cell transplantation (AHSCT) in acute myeloid leukemia (AML), and all of them have poor clinical prognosis without donor.
Methods Collect and analysis the data which failed to find an appropriate donor poor prognosis group of 10 patients with AML, schemes for the application of the preconditioning AHSCT in our department between April 2011 to March 2014.Obrvate hematopoietic reconstruction time after transplantation, transplantation related complications and follow-up.
Results 10 patients were successfully obtained hematopoietic reconstruction.
Follow-up time to March,2015, 9 patients were alive, median follow-up time was 20 months(10-38 months).Now 80% of patients are alive, and of which 70% still in CR. 3 cas of recurrence after tran
仰慕
splantation, respectively in 3 months/5 months and 6 months.2 cas are still in treatment ,1 ca died of intracranial bleeding after recurrence. The accumulative total recurrence rate was about 30%.
复发难治性AML的治疗英文摘要Conclusion IBU as preconditioning regimen for AHSCT in acute myeloid leukemia of poor clinical prognosis has good curative effect, besides the adver reactions are controllable. Tho poor prognosis of AML who did not find the suitable donor but required to take hematopoietic stem cell transplantation, it can be ud as another alternative.
Key words Acute myeloid leukemia; Poof prognosis; High-dos idarubicin; Busulphan; Autologous hematopoietic stem cell transplantation.
Written by: Cheng Yingying
Supervid by: Cao Xiangshan
目录
第一部分去甲基化联合中剂量阿糖胞苷方案在复发难治性AML中的临床应用 (1)
引言 (1)
资料与方法 (2)
结果 (3)
讨论 (4)
参考文献 (6)
第二部分强化预处理方案（IBU方案）行自体干细胞移植治疗急性髓系白血病的疗效 (10)幼儿英语视频
引言 (10)
材料与方法 (11)
结果 (13)
讨论 (14)
参考文献 (16)
结论 (19)
综述：分子遗传学在急性白血病诊断及治疗中的应用进展 (20)
良夜参考文献 (24)
中英文缩略词表 (30)
攻读学位期间公开发表的论文 (31)
致谢 (32)
