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Acute myeloid leukemia: 2014 Update on risk-stratification and management 期刊名称: American Journal of Hematology
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作者机构: Divisiontencent traveler
年份: 2014年
期号: 第11期
关键词: MINIMAL RESIDUAL DISEASE;HEMATOPOIETIC-CELL
TRANSPLANTATION;ACUTE;PROMYELOCYTIC LEUKEMIA;TRANS-RETINOIC ACID;GEMTUZUMAB OZOGAMICIN;EUROPEAN LEUKEMIANET;MONOSOMAL KARYOTYPE;INDUCTION THERAPY;DOSE教育学考研方向
摘要:Overview: Evidence suggest that even patients aged 70 or above benefit from specific AML ther
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2010年高考apy. The fundamental decision in AML then becomes whether to recommend standard or investigational treatment. This decision must rest on the likely outcome of standard treatment. Hence we review factors that predict treatment related mortality and resistance to therapy, the latter the principal cau of failure even in patients aged 70 or above. We emphasize the limitations of prediction of resistance bad only on pre-treatment factors and stress the need to incorporate post-treatment factors, for example indicators of minimal residual dia. We review various newer therapeutic options and considerations that underlie the decision to recommend allogeneic hematopoietic cell transplant. Am. J. Hematol. 89:1064–1081, 2014.
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