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英语四级旷考最新规定Prolonged relea of drug from O/w emulsion and residence in rat nasal cavity.
期刊名称： Pharmaceutical Development & Technology
same girl作者： Aikawa, Katsuyoshi,Matsumoto, Keiko,Uda, Harumi,Tanaka,
crisps>minor是什么意思货币供应Shigeo,Shimamura, Haruo,Aramaki, Yukihiko,Tsuchiya, Seishi
学英语的文章
uccal年份： 1998年
期号： 第4期noboy
关键词： Chlorpheniramine maleate;Deposit method;Dialysis tube method;Drug disappearance;Medium chain triglycerides (MCT);O/w emulsion
摘要：The prent study evaluated the ufulness of an o/w emulsion for slowing the relea of chlorphenira-mine maleate (CM) and prolonging drug residence in the nasal cavity. O/w emulsion formulations of medium chain triglycerides (MCT) were prepared, and their physicochemical properties
and drug relea kinetics were evaluated using the in vitro dialysis tube method. Drug disappearance from the rat nasal cavity was determined in in situ nasal experiments. CM partitioned in oil droplets by pH, as predicted by pH partition theory. With higher MCT concentration and pH, slower relea of CM was obrved. CM disappearance (kapp) from the rat nasal cavity was injuenced by the amount of drug partitioned in the oil droplets with both the perfusion and deposit methods, andaccidentally
the kapp of CM decread with increa in MCT concentration and pH. Moreover,...
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