Acitretin_DataSheet_MedChemExpress

更新时间:2023-06-26 23:45:49 阅读: 评论:0

Inhibitors, Agonists, Screening Libraries
Data Sheet
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BIOLOGICAL ACTIVITY:
Acitretin(Ro 10–1670) is a cond–generation, systemic retinoid that has been ud in the treatment of psoriasis.
gravelTarget: RAR/RXR
Acitretin is a cond–generation, systemic retinoid that has been approved for the treatment of psoriasis since 1997. It can be considered one of the treatments of choice for pustular and erythrodermic psoriasis. However, the efficacy of acitretin as a
monotherapy for plaque psoriasis is less, although it is often ud in combination therapy with other systemic psoriasis therapies,especially ultraviolet B or psoralen plus ultraviolet A phototherapy, to increa efficacy. Such combination treatments may potentially minimi toxicity by using lower dos of each of the two agent [1].
Thirty–nine male adult Wistar albino rats were divided into 3 groups as two experimental groups and one control group. The first group consisting 14 rats were applied orally standard do (0.75 mg/kg/day) acitretin and the cond group consisting 16 rats were applied high do (1.5 mg/kg/day)
acitretin.Acitretin was given within dimetil sulphoxide (DMSO), which was diluted with saline solution as a ratio of 1/10, in order to increa its solubility. The control group consisting 9 rats were given only saline solution
travel的过去式including DMSO for 8 weeks. After 8 weeks of the administration, half of the rats in the first and cond groups and the entire control group were sacrificed under deep ether anaesthesia and bilateral orchiectomy was made. The remainingrats were compared with the control group using a similar method at the end of 8 weeks of wash–off period. The orchiectomy materials were histopathologically evaluated under the light microscope for spermatogenesis according to parameters including spermatogenetic activity,
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spermatogenetic organization, miniferous tubular diameter, interstitial Leydig cells and fibroblasts.  In our study it was concluded that the standard and high dos of acitretin do not have any effect on the spermatogenesis of threats [2].
Clinical indications: Psoriasis
xinaFDA Approved Date:
口边
Toxicity:  naua; headache; itching; red or flaky skin; dry or red eyes; dry mouth; depression; 0cystitis acne or hair loss
References:
[1]. Lee CS, et al. A review of acitretin, a systemic retinoid for the treatment of psoriasis. Expert Opin Pharmacother. 2005 Aug;6(10):1725–34.
[2]. Seng?r B, et al. Effects of acitretin on spermatogenesis of rats. J Eur Acad Dermatol Venereol. 2006 Jul;20(6):689–92.
Product Name:
Acitretin Cat. No.:
HY-B0107CAS No.:
55079-83-9Molecular Formula:
C 21H 26O 3Molecular Weight:
平安夜英文326.43Target:downtoearth
RAR/RXR Pathway:
Metabolic Enzyme/Protea Solubility:
10 mM in DMSO
Caution: Product has not been fully validated for medical applications. For rearch u only.
Tel: 609-228-6898    Fax: 609-228-5909    E-mail: Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USAjunkmail
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