他莫昔芬单药治疗腹膜后纤维化安全有效dre>我心永恒原唱
schoolgirl摘要：目的：探讨他莫昔芬单药治疗腹膜后纤维化（RPF）的疗效。研究对象和方法：将从2007起31例进行他莫昔芬单药治疗特发性腹膜患者纳入研究，并对之后的磁共振成像、实验室检查、用药副作用、输尿管支架的拆除进行跟踪随访。结果：31例患者中包括25名男性和6名女性，平均年龄为56.6岁，进行他莫昔芬单药治疗。平均治疗时间为13.3个月，平均随访26.8个月。共44个肾单位因肾积水进行DJ支架输尿管植入术。22例影像学出现肝脏纤维化（71%）；44例肾单位中27例患者随后进行输尿管切除（61.4%）。多数单药治疗的患者仅表现为轻度或无副作用。7例（22.3%）他莫昔芬单药治疗的患者因为严重的副作用或肝纤维化的进展而不得不停药。结论：与糖皮质激素相比，他莫昔芬逆转纤维化的潜力稍微逊色以及腹膜纤维化的复发率较高，但与DJ支架输尿管植入术相比，复发率是减少的。
附原文
百度翻译英语Objective: To evaluate the therapeutic effect of tamoxifen monotherapy in patients with retroperitoneal fibrosis (RPF). Patients and Methods: From 2007 on, 31 patients with idiopathic RPF were treated with tamoxifen monotherapy. Follow-up investigations included
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昆明翻译trouble maker什么意思magnetic resonance imaging, laboratory measurements, registration of side effects and changes or removal of ureteral stents. Data were stored in the El Kr?ner-Frenius Registry of Retroperitoneal Fibrosis. Results: 25 men and 6 women with a mean age of 56.6 years were treated with tamoxifen monotherapy. Mean duration of treatment was 13.3 months, mean follow-up 26.8 months. A total of 44 renal units were affected by hydronephrosis and covered by DJ stents. Radiological regression of fibrosis was detected in 22 cas (71.0%); removal of ureteral stents was possible in 27/44 renal units (61.4%) and 17/29 patients (58.6%), respectively. Most patients showed only mild or no side effects of therapy. In 7 cas (22.3%) tamoxifen therapy had to be abandoned becau of vere side effects, progression of fibrosis or persistent intolerance. Conclusions: Tamoxifen is an alternative in the medical treatment of RPF, especially if patients want to avoid glucocorticoids. The potential of regression of fibrosis ems to be slightly inferior and the relap rate is higher compared to steroids, but the rate of successful DJ removals is comparable.
引自：Brandt AS1, Kamper L, Kukuk S, Tamoxifen Monotherapy in the Treatment of Retr欧美怀旧歌曲
operitoneal Fibrosis. 2014 S. Karger AG, Bal.
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