northwind
爱丽丝梦游仙境票房
From T-cell activation signals to signaling control of
anti-cancer immunity
期刊名称: Immunological Reviews
flower作者: Shane J. F. Cronin,Jof M. Penninger
parenthood>区间英文作者机构: IMBA, Institute of Molecular Biotechnology of the Austrian Academy
of Sciences, Vienna, Austria.
年份: 2010年
stop的用法期号: 第1期
different的名词关键词: Tcell;TCR signaling;immune synap;Vav-1;CARMA1;Cbl-b
比较级和最高级的用法>平等互利
摘要:Summary: The activation of resting T cells is crucial to most immune process. Recognition of f
oreign antigen by T-cell receptors has to be correctly translated into signal transduction events necessary for the induction of an
effective immune respon. In this review, we discuss the esntial signals, molecules, and process necessary to achieve full T-cell activation. In addition to describing the key biological events, we also discuss how T-cell receptor signaling may be harnesd to yield new therapeutic targets for a next generation of anti-cancer drugs.
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