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Product Name:
阿凡达 avatarCyproterone acetate CAS No.:
僭越是什么意思427-51-0Cat. No.:
nowokHY-13604Product Data Sheet
MWt:
402.91Formula:
C23H27ClO4Purity :>98%
Solubility:
DMSO 80 mg/mL; Water <1 mg/mL y Mechanisms:
Biological Activity:
Cyproterone acetate is an androgen receptor (AR)antagonist with IC50of 71nM as well as a weak
Pathways:Others; Target:Androgen Receptor g g
税负痛苦指数Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak
progesterone receptor agonist with weak pro-gestational and glucocorticoid activity.例如英语
Target: Androgen Receptor Cyproterone acetate clearly shows antagonistic properties, while being a partial agonist also,showing agonism for the AR, with EC50 of 4.0 μM, at relatively high concentrations [1]. In the prence of 10 nM Testosterone, low concentrations of Cyproterone acetat
e inhibits T-stimulated transcription of 3XHRE-LUC, but at higher concentrations, transcription is stimulated. LH levels in Cyproterone acetate-treated rats do not dip below pretreatment levels, although they does not increa as much in the rats treated with 3.2 mg Cyproterone acetate/kg/day as in tho which References:
柯南配音还珠格格
[1]. Sonneveld, E., et al., Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-bad highly lective steroid-responsive bioassays. Toxicol Sci, 2005.
83(1): p. 136-48.g yp g y
received 0.2 mg Cyproterone acetate/kg/day [2]. Cyproterone acetate exhibits direct [2]. Attardi, B.J., S. Koduri, and S.A. Hild, Relative progestational and androgenic activity of four progestins ud for male hormonal contraception assd in vitro in relation to their ability to
suppress LH cretion in the castrate male rat. Mol Cell Endocrinol, 2010. 328(1-2): p. 16-21.[3]. Arafa, N.M., Efficacy of echinacea on the action of cyproterone acetate in male rats. Pak J Biol
Sci, 2010. 13(20): p. 966-76.Caution: Not fully tested. For rearch purpos only
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