专利名称：NOGO-A POLYPEPTIDE FRAGMENTS, VARIANT NOGO RECEPTOR-1
绯闻女孩第三季POLYPEPTIDES, AND USES THEREOF 发明人：STRITTMATTER, Stephen, M.
东正教教堂申请号：US2005035719
申请日：20051003
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公开号：WO06/047049P1posh spice
公开日：
20060504
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摘要：Nogo, MAG, and OMgp are myelin-derived proteins that bind to a neuronal Nogo-66 Receptor (NgR) to limit axonal regeneration after CNS injury. Nogo-A protein may play the most prominent role in vivo, perhaps becau its action is mediated both by NgR and by other receptors. Here, we extend our previous analysis of Nogo-A and NgR functional domains. In addition to a NgR-dependent Nogo-66 inhibitory domain and a NgR-independent Amino-Nogo-A specific domain, we identify a third Nogo-A specific domain that binds to NgR with nanomolar affinity. This third domain of 19 amino acids (aa) does not alter cell spreading or axonal outgrowth. Ala-scanning mutagenesis of surface residues in NgR partially distinguishes ligand binding sites for the two Nogo domains and for MAG, OMgp and Lingo-1. Fusion of the two NgR-binding Nogo-A domains creates a ligand with ten-fold enhanced affinity for NgR and converts a NgR antagonist peptide to an agonist. Thus, inhibition of axonal regeneration by NgR occurs after binding a subnanomolar bipartite Nogo-A ligand at a site partly overlapping with that for MAG and OMgp.
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申请人：STRITTMATTER, Stephen, M.
地址：US,US
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国籍：US,US
代理机构：STEFFE, Eric, K.更多信息请下载全文后查看
