Product Note Agilent 6530 Accurate-Mass
Q-TOF LC/MS
Exceptional MS and MS/MS performance without compromis
The Agilent 6530 Accurate-Mass Quadrupole Time-of-Flight (Q-TOF) LC/MS system features Agilent Jet Stream Thermal Focusing technology for signif-icantly improved nsitivity, as well as enhanced MassHunter Workstation software for superior data mining and analysis capabilities. The new fea-tures, coupled with Agilent’s True High-Defi nition TOF (True Hi-Def TOF) tech-nology, enable the 6530 Accurate-Mass Q-TOF to deliver exceptional nsitivity, excellent mass accuracy, fast data acquisition, and streamlined qualitative and quantitative analys to meet your most challenging rearch needs.
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Sensitive, Accurate-Mass MS
and MS/MS Analys
The Agilent 6530 Accurate-Mass Q-TOF LC/MS system is designed to provide superior data quality and advanced analytical capabilities for profi ling, iden-tifying, characterizing, and quantifying low molecular-weight compounds and biomolecules with confi dence. Integrat-ing three core Agilent techni
cal inno-vations—True Hi-Def TOF technology, Agilent Jet Stream Thermal Focusing technology and MassHunter Worksta-tion software—the 6530 Q-TOF platform is ideally suited for accurate-mass analy-s of the complex samples encountered in today’s most demanding applications.
Exceptional Mass Accuracy, Sensitivity, and Speed
Agilent True Hi-Def TOF technology,
a key feature of Agilent’s 6500 Series全文翻译
Q-TOF LC/MS instruments, delivers outstanding Q-TOF performance char-acteristics without any performance compromis.
• Sub 1-ppm mass accuracy improves confi dence and reduces fal positives
• > 20,000 mass resolution distinguishes target analytes from interferences
• Up to 5 orders of in-spectrum dynamic range improves detection of trace-level targets in the prence of high- abundance compounds
• High femtogram nsitivity enables identifi cation of very low-abundance compounds
• Fast data acquisition rates of up to
40 spectra/cond ensure maximum compatibility with fast LC and high-throughput methods
• Wide mass range to 20,000 m/z
Agilent 6530 Accurate-Mass Q-TOF LC/MS integrates True Hi-Def TOF technology, Agilent Jet Stream Thermal Focusing technology, and MassHunter Workstation software for nsitive,
accurate-mass MS and MS/MS analys.
Product Note
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This item is intended for Rearch U Only. Not for u in diagnostic procedures.
Enhances LC/MS Sensitivity 5- to 10-fold
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Agilent Jet Stream Thermal Focusing technology signifi cantly increas LC/MS nsitivity by improving the
spatial focusing of electrospray droplets. The subquent enhancements in ion density and desolvation result in higher MS signal intensities and improved signal-to-noi ratios. On average, a 5- to 10-fold improvement in MS and
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MS/MS nsitivity is realized by using Agilent Jet Stream technology at optimal LC fl ow rates. Easy to u and tune, Agilent Jet Stream technology is avail-able on the 6530 Accurate-Mass Q-TOF LC/MS to provide maximum nsitivity for multiple applications, including the analysis of drug candidates and trace levels of food contaminants, metabolites or biomarkers.
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Powerful Data Mining and Analysis Capabilities
Agilent’s MassHunter Workstation software facilitates faster and easier processing of information-rich data generated by the 6530 Accurate-Mass Q-TOF LC/MS. Compound-centric data mining and navigation capabilities enable effi cient analys of complex MS data. A sophisticated molecular feature extraction algorithm automatically
Agilent Jet Stream Thermal Focusing technology utilizes super-heated nitrogen sheath gas to confi ne the electrospray. Ion density and desolvation are improved, resulting in higher MS signal intensities and reduced noi.
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Agilent 6530 Accurate-Mass Q-TOF LC/MS
/chem/qtof
retrieves all spectral and chromatographic information for each component in a sample mixture, including tho in over-lapping and co-eluting peaks, thereby saving hours of analysis time. Mass-Hunter’s integrated mass profi ling tools streamline differential and statistical analys between sample ts. The soft-ware can be ud to perform additional processing steps such as molecular formula generation, databa or library arch, deconvolution, isotope pattern
matching or charge-state determination for confi dent compound identifi cation.
圣诞节快乐英语怎么读Designed for the Most Demanding Applications
The Agilent 6530 Accurate-Mass Q-TOF LC/MS system delivers exceptional MS and MS/MS analys for applications that demand the highest accurate-mass measurements, without compromising nsitivity and speed. Integration of Agilent Jet Stream Thermal Focusing
technology ensures the highest level of nsitivity for your most challenging samples. Powerful new data mining tools facilitate profi ling, characteriza-tion, identifi cation and quantifi cation of compounds in complex mixtures. The performance characteristics enable the 6530 Q-TOF system to support demand-ing applications such as proteomics, metabolomics, impurity testing, product degradation studies, forensics, food safety, and environmental analys.
A 5-fold gain in signal intensity is obrved with Agilent Jet Stream technology. Comparison of the LC-MS/MS spectra of a 1 pg sample of the drug rerpine obtained using a conventional Agilent ESI source with the Agilent 6520 Q-TOF instrument, and using Agilent Jet Stream technology integrated into the Agilent 6530 Q-TOF platform.
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医疗保险英文About Agilent Technologies
Agilent Technologies is a leading supplier of life science rearch systems that enable scientists to understand complex biological process, determine dia mechanisms, and speed drug
discovery. Engineered for nsitivity, reproducibility, and workfl ow productivity, Agilent’s life science solutions include instrumentation, microfl uidics, software, microarrays, consumables, and rvices for genomics, proteomics, and metabolomics applications.
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This item is intended for Rearch U Only.
Not for u in diagnostic procedures. Information, descriptions, and specifi cations in this publication are subject to change without notice.
Agilent Technologies shall not be liable for errors contained herein or for incidental or conquential damages in connection with the furnishing, performance or u of this material.© Agilent Technologies, Inc. 2008Printed in the U.S.A. August 28, 20085989-9397EN
Improved nsitivity with Agilent Jet Stream technology enabled the identifi cation of four times more
low-level metabolites compared with the standard ESI source. Summary of the ritonavir metabolites in liver microsomes identifi ed by LC/MS using a conventional Agilent ESI source with the Agilent 6520 Q-TOF instrument, and using Agilent Jet Stream technology integrated into the Agilent 6530 Q-TOF platform.
Agilent Jet Stream technology
ESI source
Targeted analytes are detectable at 1 pg, with RSD of <20% for all analytes. LC/MS analysis of a 100 ppt mixture of pesticide standards in a tomato matrix using Agilent Jet Stream technology on an Agilent 6530 Q-TOF platform.
