vitamin d

更新时间:2023-01-03 20:10:38 阅读: 评论:0


2023年1月3日发(作者:ejb开发)

VitaminDandcoloncancer

LidijaKlampfer

【期刊名称】《世界胃肠肿瘤学杂志:英文版(电子版)》

【年(卷),期】2014()11

【摘要】Calcitriol,1α,25-dihydroxyvitaminD3(1,25(OH)2D3),themost

activeformofvitaminD,isapleotropichormonewithawiderangeof

tsabilitytoregulatecalciumandphosphate

metabolism,1,tion,1,25D3

bindstothevitaminDreceptorandtherebyregulatestheexpressionofa

numberofgeneswhichcontrolgrowth,differentiationandsurvivalof

ement,thelevelsofvitaminD3appeartobean

esntialdeterminantforthedevelopmentandprogressionofcolon

cancerandsupplementationwithvitaminD3iffectiveinsuppressing

nD3hasbeenestimated

tolowertheincidenceofcolorectalcancerby50%,whichisconsistentwith

theinvercorrelationbetweendietaryvitaminD3intakeorsunlight

lstudiesconfirmedthat

increasingvitaminD3lowerscoloncancerincidence,reducespolyp

recurrence,andthatsufficientlevelsofvitaminD3areassociatedwith

nDregulatesthe

homeostasisofintestinalepitheliumbymodulatingtheoncogenicWnt

activitiescontributetotheabilityof1,25D3topreventthedevelopment

andprogressionofcoloncancer.

【总页数】8页(P430-437)

【关键词】

Colon;cancer;Vitamin;D;Wnt;signaling;Inflammation;Chemoprevention

【作者】LidijaKlampfer

【作者单位】SouthernRearchInstitute,Birmingham

【正文语种】中文

【中图分类】R735.35

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