VitaminDandcoloncancer
LidijaKlampfer
【期刊名称】《世界胃肠肿瘤学杂志:英文版(电子版)》
【年(卷),期】2014()11
【摘要】Calcitriol,1α,25-dihydroxyvitaminD3(1,25(OH)2D3),themost
activeformofvitaminD,isapleotropichormonewithawiderangeof
tsabilitytoregulatecalciumandphosphate
metabolism,1,tion,1,25D3
bindstothevitaminDreceptorandtherebyregulatestheexpressionofa
numberofgeneswhichcontrolgrowth,differentiationandsurvivalof
ement,thelevelsofvitaminD3appeartobean
esntialdeterminantforthedevelopmentandprogressionofcolon
cancerandsupplementationwithvitaminD3iffectiveinsuppressing
nD3hasbeenestimated
tolowertheincidenceofcolorectalcancerby50%,whichisconsistentwith
theinvercorrelationbetweendietaryvitaminD3intakeorsunlight
lstudiesconfirmedthat
increasingvitaminD3lowerscoloncancerincidence,reducespolyp
recurrence,andthatsufficientlevelsofvitaminD3areassociatedwith
nDregulatesthe
homeostasisofintestinalepitheliumbymodulatingtheoncogenicWnt
activitiescontributetotheabilityof1,25D3topreventthedevelopment
andprogressionofcoloncancer.
【总页数】8页(P430-437)
【关键词】
Colon;cancer;Vitamin;D;Wnt;signaling;Inflammation;Chemoprevention
【作者】LidijaKlampfer
【作者单位】SouthernRearchInstitute,Birmingham
【正文语种】中文
【中图分类】R735.35
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