insulin

专利名称：ACYLATEDINSULIN

发明人：HAVELUND,Svend,HALSTROM,John

Broberg,JONASSEN,Ib,ANDERSEN,Asr

Sloth,MARKUSSEN,Jan

申请号：EP94926816.3

申请日：19940916

公开号：EP0792290B1

公开日：20010829

专利内容由知识产权出版社提供

摘要：Theprentinventionrelatestoprotractedhumaninsulinderivativesinwhich

theA21andtheB3aminoacidresiduesare,independently,anyaminoacidresiduewhich

canbecodedforbythegeneticcodeexceptLys,ArgandCys;PheB1maybedeleted;the

B30aminoacidresidueisa)anon-codable,lipophilicaminoacidhavingfrom10to24

carbonatoms,inwhichcaanacylgroupofacarboxylicacidwithupto5carbonatoms

isboundtothe⊂-aminogroupofLysB29;orb)theB30aminoacidresidueisdeletedoris

anyaminoacidresiduewhichcanbecodedforbythegeneticcodeexceptLys,Argand

Cys,inanyofwhichcasthe⊂-aminogroupofLysB29hasalipophilicsubstituent;and

anyZn2+complexesthereofwiththeprovisothatwhenB30isThrorAlaandA21andB3

arebothAsn,andPheB1isprent,thentheinsulinderivativeisalwaysprentasaZn2+

complex.

申请人：NOVONORDISKAS

地址：DK

国籍：DK

代理机构：Jorgenn,Dan

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