combination

专利名称：COMBINATIONDRUGS

发明人：DOI,Takayuki,HASHIMOTO,

Tadatoshi,KAMO,Izumi

申请号：EP01271853.2

申请日：20011221

公开号：EP1352659A1

公开日：20031015

专利内容由知识产权出版社提供

摘要：ApharmaceuticalagentcontaininganNK-1receptorantagonist,anNK-2

receptorantagonistand/orananti-cholinergicdrugincombinationisprovided,whichis

ufulasaprophylacticortherapeuticagentofurinaryfrequency,urinaryincontinence,

asthma,chronicobstructivepulmonarydia,rheumatoidarthritis,osteoarthritis,pain,

cough,irritablebowelsyndrome,emesis,depression,anxiety,manicdepressivepsychosis

rticularly,apharmaceuticalagentisprovided,whichcontainsa

compoundreprentedbytheformula(I),whereinMringisaheterocyclicringhaving-

N=C<,-CO-N

toformringA,orthesameordifferentandeachisahydrogenatomorasubstituentfor

ringM;ringAandringBareeachahomocyclicorheterocyclicringoptionallyhaving

substituentsandatleastoneofthemisaheterocyclicringoptionallyhavingsubstituents;

ringCisahomocyclicorheterocyclicringoptionallyhavingsubstituents;ringZisan

optionallysubstitutedheterocyclicringcontainingnitrogen;andnisanintegerof1to6,

orasaltthereoforaprodrugthereof,andanNK-2receptorantagonistand/orananti-

cholinergicdrugincombination.

申请人：TakedaChemicalIndustries,Ltd.

地址：1-1Doshomachi4-chome,Chuo-kuOsaka-shi,Osaka541-0045JP

国籍：JP

代理机构：vonKreisler,Alek,Dipl.-Chem.

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